diff --git a/Gemfile b/Gemfile
index 61c8daa42..0c2c68fbd 100644
--- a/Gemfile
+++ b/Gemfile
@@ -89,6 +89,7 @@ gem "rubyzip", "~> 2.3" # Rubyzip is a ruby library for reading and writing zip
 gem "s3_direct_upload", "~> 0.1" # Direct Upload to Amazon S3
 gem "sass-rails", "~> 6.0" # Sass adapter for the Rails asset pipeline
 gem "sidekiq", "~> 6.0.6" # Sidekiq is used to process background jobs with the help of Redis
+gem "sidekiq-unique-jobs", "~> 6.0.21" # Ensures that Sidekiq jobs are unique when enqueued
 gem "sitemap_generator", "~> 6.1" # SitemapGenerator is a framework-agnostic XML Sitemap generator
 gem "slack-notifier", "~> 2.3" # A slim ruby wrapper for posting to slack webhooks
 gem "sprockets", "~> 4.0" # Sprockets is a Rack-based asset packaging system
diff --git a/Gemfile.lock b/Gemfile.lock
index 67892fd64..0395b6f80 100644
--- a/Gemfile.lock
+++ b/Gemfile.lock
@@ -745,6 +745,10 @@ GEM
       rack (~> 2.0)
       rack-protection (>= 2.0.0)
       redis (>= 4.1.0)
+    sidekiq-unique-jobs (6.0.21)
+      concurrent-ruby (~> 1.0, >= 1.0.5)
+      sidekiq (>= 4.0, < 7.0)
+      thor (~> 0)
     signet (0.13.0)
       addressable (~> 2.3)
       faraday (>= 0.17.3, < 2.0)
@@ -987,6 +991,7 @@ DEPENDENCIES
   sdoc (~> 1.1)
   shoulda-matchers (~> 4.3.0)
   sidekiq (~> 6.0.6)
+  sidekiq-unique-jobs (~> 6.0.21)
   simplecov (= 0.17.1)
   sitemap_generator (~> 6.1)
   slack-notifier (~> 2.3)
diff --git a/app/workers/articles/bust_cache_worker.rb b/app/workers/articles/bust_cache_worker.rb
index e1876e996..53c741a8b 100644
--- a/app/workers/articles/bust_cache_worker.rb
+++ b/app/workers/articles/bust_cache_worker.rb
@@ -2,7 +2,7 @@ module Articles
   class BustCacheWorker
     include Sidekiq::Worker
 
-    sidekiq_options queue: :high_priority, retry: 10
+    sidekiq_options queue: :high_priority, retry: 10, lock: :until_executing
 
     def perform(article_id, cache_buster = "CacheBuster")
       article = Article.find_by(id: article_id)
diff --git a/app/workers/comments/calculate_score_worker.rb b/app/workers/comments/calculate_score_worker.rb
index 0d444df7a..52344600b 100644
--- a/app/workers/comments/calculate_score_worker.rb
+++ b/app/workers/comments/calculate_score_worker.rb
@@ -2,7 +2,7 @@ module Comments
   class CalculateScoreWorker
     include Sidekiq::Worker
 
-    sidekiq_options queue: :medium_priority
+    sidekiq_options queue: :medium_priority, lock: :until_executing
 
     def perform(comment_id)
       comment = Comment.find_by(id: comment_id)
diff --git a/app/workers/notifications/update_worker.rb b/app/workers/notifications/update_worker.rb
index 51cbca345..1e2867ae6 100644
--- a/app/workers/notifications/update_worker.rb
+++ b/app/workers/notifications/update_worker.rb
@@ -2,7 +2,7 @@ module Notifications
   class UpdateWorker
     include Sidekiq::Worker
 
-    sidekiq_options queue: :medium_priority, retry: 10
+    sidekiq_options queue: :medium_priority, retry: 10, lock: :until_executing
 
     def perform(notifiable_id, notifiable_class, action = nil)
       raise InvalidNotifiableForUpdate, notifiable_class unless %w[Article Comment].include?(notifiable_class)
diff --git a/app/workers/search/index_to_elasticsearch_worker.rb b/app/workers/search/index_to_elasticsearch_worker.rb
index c01081f07..cf16835c6 100644
--- a/app/workers/search/index_to_elasticsearch_worker.rb
+++ b/app/workers/search/index_to_elasticsearch_worker.rb
@@ -2,7 +2,7 @@ module Search
   class IndexToElasticsearchWorker
     include Sidekiq::Worker
 
-    sidekiq_options queue: :high_priority
+    sidekiq_options queue: :high_priority, lock: :until_executing
 
     def perform(object_class, id)
       # PodcastEpisodes and Articles share an index so their IDs are prepended with their class names
diff --git a/app/workers/search/remove_from_elasticsearch_index_worker.rb b/app/workers/search/remove_from_elasticsearch_index_worker.rb
index e74353a7d..3f5289864 100644
--- a/app/workers/search/remove_from_elasticsearch_index_worker.rb
+++ b/app/workers/search/remove_from_elasticsearch_index_worker.rb
@@ -2,7 +2,7 @@ module Search
   class RemoveFromElasticsearchIndexWorker
     include Sidekiq::Worker
 
-    sidekiq_options queue: :medium_priority
+    sidekiq_options queue: :medium_priority, lock: :until_executing
 
     def perform(search_class, id)
       search_class.safe_constantize.delete_document(id)
diff --git a/config/initializers/sidekiq_unique_jobs.rb b/config/initializers/sidekiq_unique_jobs.rb
new file mode 100644
index 000000000..0261ad516
--- /dev/null
+++ b/config/initializers/sidekiq_unique_jobs.rb
@@ -0,0 +1,3 @@
+SidekiqUniqueJobs.configure do |config|
+  config.enabled = !Rails.env.test?
+end
diff --git a/config/routes.rb b/config/routes.rb
index 1ab23b4d8..293d6ce4c 100644
--- a/config/routes.rb
+++ b/config/routes.rb
@@ -11,6 +11,8 @@ Rails.application.routes.draw do
   }
 
   require "sidekiq/web"
+  require "sidekiq_unique_jobs/web"
+
   authenticated :user, ->(user) { user.tech_admin? } do
     Sidekiq::Web.set :session_secret, Rails.application.secrets[:secret_key_base]
     Sidekiq::Web.set :sessions, Rails.application.config.session_options